IHME：2025痴呆症风险因素研究报告：美国12项致病因素的暴露水平与影响系统评估（全国及各州）（英文版）（199页）.pdf

1、 Dementia Risk Factors Project A systematic evaluation of exposure and impact of 12 drivers of disease in the United States,overall and by state Final Report Prepared by IHME Client Services July 31,2025 1 Contents 1 Executive Summary.6 2 Project Background.7 3 Methods.8 3.1 Analytic Framework.8 3.2

2、 Risk Exposure.8 3.3 Dementia Burden.10 3.4 Data Landscaping to Inform Relative Risk Models.10 3.4.1 Systematic literature review methods.11 3.4.2 Dementia case definition.11 3.4.3 Study quality and bias assessment.12 3.5 Burden of Proof Risk Function.13 3.6 Population Attributable Fraction and Attr

3、ibutable Burden.16 4 Key Takeaways.17 5 Results by Risk Factor.24 5.1 Air Pollution.24 5.1.1 Exposure definition.24 5.1.2 National-level and state-level exposure and disparities.24 5.1.3 Data landscape.26 5.1.4 Evidence score summaries.29 5.1.5 Sub-analyses.29 5.1.6 Population attributable fraction.

4、31 5.1.7 Attributable burden.32 5.1.8 Major takeaways.34 5.2 Alcohol.36 5.2.1 Exposure definition.36 5.2.2 National-level and state-level exposure and disparities.36 5.2.3 Data landscape.38 5.2.4 Evidence score summaries.41 5.2.5 Population attributable fraction.41 5.2.6 Attributable burden.41 5.2.7

5、 Major takeaways.42 2 5.3 Body Mass Index.43 5.3.1 Exposure definition.43 5.3.2 National-level and state-level exposure and disparities.43 5.3.3 Data landscape.45 5.3.4 Evidence score summaries.49 5.3.5 Population attributable fraction.50 5.3.6 Attributable burden.50 5.3.7 Major takeaways.50 5.4 Dep

6、ression.51 5.4.1 Exposure definition.51 5.4.2 National-level and state-level exposure and disparities.51 5.4.3 Data landscape.53 5.4.4 Evidence score summaries.56 5.4.5 Sub-analyses.57 5.4.6 Population attributable fraction.58 5.4.7 Attributable burden.60 5.4.8 Major takeaways.62 5.5 Education.64 5.