赛默飞PPD：2024蚊媒疾病：登革热和药物研发进展白皮书（英文版）（9页）.pdf

1、Navigating the mosquito-borne disease landscape:a focus on dengue and advancements in drug developmentVaccine trialsWhite paperppdIntroduction While scientists around the world are concerned about the microorganism that will spread the next pandemic,the“worlds most deadly animal”(according to the US

2、 CDC Centers for Disease Control and Prevention)is spreading its wings.Mosquitos are highly effective vectors in transmitting debilitating infectious diseases which pose a major health threat to humans.Mosquitoes infect more than 700 million people globally and cause over 1 million deaths each year.

3、3There are at least six diseases causing almost three-quarters of a million deaths worldwide each year:1 Malaria-by far the deadliest-is transmitted by the Anopheles mosquito and causes around 250 million infections and up to half a million deaths,mainly in sub-Saharan Africa and many in children.Zi

4、ka Virus-transmitted mainly by the Aedes mosquito,the virus was associated with a large outbreak of miscarriages and congenital malformations centered in Brazil.Yellow Fever-a potentially deadly disease also transmitted by the Aedes mosquito species,predominantly affecting people in sub-Saharan Afri

5、ca and South America.Dengue-another Aedes-transmitted infection that is endemic in over 100 countries and causes upwards of 400 million infections every year,strains on healthcare systems,and occasional deaths reported.Chikungunya-yet another widespread Aedes-transmitted infection that causes severa

6、l million cases a year,which can neither be prevented by vaccines nor treated by specific drugs.West Nile Virus-spread by the Culex mosquito and usually causes no symptoms but can cause severe disease in those who are vulnerable through depressed immune systems.Worldwide spread an emerging threat Wh