In 2025, the Latin America and Caribbean region was represented by 26 countries, with a total of 325 qualified cities reporting PM2.5 data. Three fewer countries (ist countries) met the reporting threshold compared to 2024, reflecting modest changes in regional data availability. At the city level, air quality trends were largely positive. A total of 208 cities recorded decreases in annual average PM2.5 concentrations, while 95 cities experienced increases, nine remained unchanged, and 13 new cities were added to the dataset. At the national level, six countries saw increases in their annual average PM2.5 concentrations, 19 reported decreases, and one country remained unchanged, continuing the broader regional pattern of gradual improvement. Honduras recorded the largest decline, with its national annual average PM2.5 concentration falling from 15.2 μg/m3 to 6.3 μg/m3, a reduction of 59%. The drought conditions of the 2023, 2024 El Nino season, which created a landscape highly prone to wildfires, Range of 2025 average PM2.5 (μg/m3) across regional cities subsided with the transition to La Nina for Central American countries. This shift lowered PM2.5 levels by introducing increased rainfall and wind speeds starting in late 2024 and continuing throughout 2025 for Honduras, Guatemala, Nicaragua and El s al e pa nd so ui is from a 2024 PM2.5 concentration of 17.1 μg/m3 to 19.1 μg/m3 in 2025; Anguila also recorded a modest rise from 7.4 μg/m3 to 8 μg/ m3, an increase of 8%. Six countries and teritories in the region, Puerto Rico, U.S. Virgin Islands, Barbados, Bermuda, Grenada, and Panama, reported annual average PM2.5 concentrations that meet WHO guideline of 5 μg/m3, while Peru, Mexico, and Chile, ll reporing 2025PM2.5concentrtions greater than15μg/m, continue to exceed the WHO Interim Target 2. The air quality monitoring network in the Latin America and Caribbean region continued to expand in 2025, with 13 new cities added to the regional dataset. Most of these new locations reported relatively low polution levels, as nine of the 13 cities recorded Brazil led all countries in the number of newly added cities, contributing four of the 13 new locations, followed by Peru with three. With 77 cities meeting data availability requirements, Mexico continued to report the highest number of cities in the region, followed by Chile with 72, Brazil with 57, and Peru with 41. The composition of the monitoring network also highlights the now account for 29% of all stations in the region, helping to